Wu JI, Lessard J, Olave IA, Qiu Z, Ghosh A, Graef IA, Crabtree GR.
Regulation of dendritic development by neuron-specific chromatin remodeling complexes.
Neuron. 2007 Oct 4;56(1):94-108.
Abstract PDF Supplemental Data

An essential switch in subunit composition of a chromatin remodeling complex during neural development.

Lessard J, Wu JI, Ranish JA, Wan M, Winslow MM, Staahl BT, Wu H, Aebersold R, Graef IA, Crabtree GR.
Neuron. 2007 Jul 19;55(2):201-15.
Abstract PDF Supplemental Data
Commentary in Neuron by S. Aigner, A. Denli and F.Gage: PDF

NFAT signaling and the invention of vertebrates.
Wu H, Peisley A, Graef IA, Crabtree GR.
Trends Cell Biol. 2007 Jun;17(6):251-60.
Abstract PDF.

Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons.
Zhou X, Babu JR, da Silva S, Shu Q, Graef IA, Oliver T, Tomoda T, Tani T, Wooten MW, Wang F.
Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5842-7
Abstract PDF.

NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21.
Arron JR, Winslow MM, Polleri A, Chang CP, Wu H, Gao X, Neilson JR, Chen L, Heit JJ, Kim SK, Yamasaki N, Miyakawa T, Francke U, Graef IA, Crabtree GR.
Nature. 2006 Jun 1;441(7093):595-600. Epub 2006 Mar 22.
Abstract PDF Supplemental Data
Commentary by C. Epstein: PDF
Review by S. de la Luna and X. Estivill: PDF

'Nature-inspired' drug-protein complexes as inhibitors of Abeta aggregation.
Bose M, Gestwicki JE, Devasthali V, Crabtree GR, Graef IA.
Biochem Soc Trans. 2005 Aug;33(Pt 4):543-7. Review
Abstract PDF

Harnessing chaperones to generate small-molecule inhibitors of amyloid beta aggregation
Gestwicki JE, Crabtree GR, Graef IA.
Science. 2004 Oct 29;306(5697):865-9
Abstract PDF Supplemental Data
Commentary in Science by I.Wickelgren: PDF
Commentary in New England Journal of Medicine by J.Kelly: PDF
Commentary in Nature Reviews in Drug Discovery by A. Rowan: PDF

News

American Chemical Society: http://pubs.acs.org/cen/news/8244/8244notw1.html
Alzheimer Research Forum: http://www.alzforum.org/new/detail.asp?id=1101
BBC News: http://news.bbc.co.uk/2/hi/health/3959381.stm
Scientific American: http://www.sciam.com/article.cfm?articleID=0000A972-6E3D-1181-AE3D83414B7F0000

A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis.
Chang CP, Neilson JR, Bayle JH, Gestwicki JE, Kuo A, Stankunas K, Graef IA, Crabtree GR.
Cell. 2004 Sep 3;118(5):649-63
Abstract PDF

Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons
Graef IA, Wang F, Charron F, Chen L, Neilson J, Tessier-Lavigne M, Crabtree GR.
Cell. 2003 May 30;113(5):657-70.
Abstract PDF

NFAT signaling in vertebrate development.
Graef IA, Chen F, Crabtree GR.
Curr Opin Genet Dev. 2001 Oct;11(5):505-12. Review
Abstract PDF

Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature.
Cell. 2001 Jun 29;105(7):863-75.
Graef IA, Chen F, Chen L, Kuo A, Crabtree GR.
Abstract PDF

Evolutionary relationships among Rel domains indicate functional diversification by recombination.
Graef IA, Gastier JM, Francke U, Crabtree GR.
Proc Natl Acad Sci U S A. 2001 May 8;98(10):5740-5
Abstract PDF

L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons.
Graef IA, Mermelstein PG, Stankunas K, Neilson JR, Deisseroth K, Tsien RW, Crabtree GR.
Nature. 1999 Oct 14;401(6754):703-8
Abstract PDF

Proximity and orientation underlie signaling by the non-receptor tyrosine kinase ZAP70.
Graef IA, Holsinger LJ, Diver S, Schreiber SL, Crabtree GR.
EMBO J. 1997 Sep 15;16(18):5618-28.
Abstract PDF